![]() ![]() On the other hand, a reduction in serum insulin through the use of diazoxide to supress insulin secretion is reported to significantly reduce the serum testosterone ( 1, 2). Furthermore, it has been shown that acute increment in insulin levels in the women with PCOS induces rises in androgen levels ( 2). Moreover, ovaries removed from the women with PCOS exhibited enhanced androstenedione and testosterone release in response to insulin stimulation ( 1). Evidence from in vivo and in vitro studies suggests that insulin has both direct and indirect effects on androgen levels. Insulin sensitivity is impaired in PCOS and this finding holds in both the presence and absence of obesity ( 3). Nearly 20% of obese women with PCOS have an impaired Glucose Tolerance Test (GTT) or diabetes ( 1). Insulin resistance with compensatory hyperinsulinemia appears to be the most universal feature of the polycystic ovarian disease and has a pathophysiologic role in the hyperandrogenism of the disorder ( 2). It is the most prevalent cause of female infertility and is characterized by ovarian hyperandrogenism and chronic anovulation. Polycystic Ovary Syndrome (PCOS) is a form of functional ovarian hyperandrogenism which affects approximately 5-10% of the women in the reproductive age ( 1). Overall, chromium picolinate was better tolerated compared to metformin nonetheless, the two study groups were not significantly different regarding ovulation and pregnancy rates. ![]() These effects were comparable with metformin however, metformin treatment was associated with decreased hyperandrogenism. Nevertheless, no significant difference was found between the two study groups regarding ovulation (p=0.417) and pregnancy rates (p=0.500).Ĭonclusion: Chromium picolinate decreased FBS and insulin levels and, thus, increased insulin sensitivity in clomiphene citrate-resistance PCOS women. In comparison to the patients who received chromium picolinate, those who received metformin had significantly lower levels of testosterone (p=0.001) and free testosterone (p=0.001) after 3 months of treatment. In the same way, the serum levels of fasting insulin had significantly decreased leading to an increase in insulin sensitivity as measured by QUICKI index (p=0.014). Results: Chromium picolinate significantly decreased fasting blood sugar (FBS) after 3 months of treatment (p=0.042). Ovulation and pregnancy rate was measured in the two study groups, as well. Anthropometric and hormonal profile were measured and compared both before and after the treatment. The subjects were randomly assigned to two groups receiving either chromium picolinate (200µg daily) or metformin (1500mg daily) for 3 months. Materials and Methods: The present randomized clinical trial was performed on 92 women with clomiphen citrate-resistant PCOS at the clinics which were affiliated to Shiraz University of Medical Sciences, Shiraz, Iran. metformin in clomiphen citrate resistant PCOS patients. Objective: To compare the effects of chromium picolinate vs. Background: Chromium picolinate could be effective in clomiphen citrate resistant PCOS patients. ![]()
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